Robert Anton Wilson in 2004 was not in great physical shape and was mourning the death of his wife, Arlen. He had to be persuaded to give an interview when James Nye flew from the United Kingdom. But in this interview which popped up again on YouTube this summer, he is positive and cheerful and has good things to say about maintaining a good attitude toward life, how to read Illuminatus! and more. About 11 minutes.
Nye also has a Ken Campbell's Meaning of Life interview, close to two hours long.
Email to the Universe has a 1994 interview of RAW by Nye.
See also RAW Semantics on Twitter, where I found out about this interview.