The SMI2LE formula endorsed by Timothy Leary and Robert Anton Wilson calls for space migration, intelligence increase and life extension.
You could argue that space migration is on the way, given that space exploration is becoming cheaper with the SpaceX reusable rockets and all of the new advances in AI would seem to argue for increased intelligence (even if following politics convinces you people actually are getting dumber.) But where is life extension?
That's arriving, too, according to Lifespan: Why We Age—And Why We Don’t Have To by Harvard Medical School professor David Sinclair.
Here is a summary from Richard Hanania: "Sinclair, a professor at Harvard Medical School, all but guarantees the reader immortality. Again and again, he tells you the end of aging is coming. And not only that, it’s coming soon. And not only will we stop aging, but we’re probably going to reverse aging any second now, if we can’t already."
Hanania's piece is mostly about how he plans to apply Sinclair's advice, but Scott Alexander has written a long book review.